Recent trends in orexin research-2010 to 2015

被引：73

作者：

Boss, Christoph ^{[1
]}

Roch, Catherine ^{[2
]}

机构：

[1] Actel Pharmaceut Ltd, Drug Discovery Chem, CH-4123 Allschwil, Switzerland

[2] Actel Pharmaceut Ltd, Drug Discovery Pharmacol, CH-4123 Allschwil, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 15期

关键词：

Orexin; G-protein-coupled receptors; Sleep disorders; Anxiety; Addiction; Hypothalamus; RECEPTOR ANTAGONIST 2-SORA; SLEEP; DISCOVERY; POTENT; TETRAHYDROISOQUINOLINES; HYPOTHALAMUS; HYPOCRETINS; ACT-462206; EXPRESSION; NARCOLEPSY;

D O I：

10.1016/j.bmcl.2015.05.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Specific neurons in the lateral hypothalamus produce the orexin neuropeptides (orexin-A and orexin-B). The orexin-peptides are transported to areas of the brain regulating sleep-wake cycles, controlling food intake or modulating emotional states such as panic or anxiety. The orexin system, consisting of the two orexin-neuropeptides and two G-protein-coupled receptors (the orexin-1 and the orexin-2 receptor) is as well involved in reward and addictive behaviors. The review reflects on the most recent activities in the field of orexin research. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2875 / 2887

页数：13

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