Effects of lacosamide "a novel antiepileptic drug" in the early stages of chicken embryo development

被引：18

作者：

Mete, Mesut ^{[1
]}

Gurcu, Beyhan ^{[2
,3
]}

Collu, Fatih ^{[2
,3
]}

Unsal, Ulkun Unlu ^{[1
]}

Duransoy, Yusuf Kurtulus ^{[1
]}

Tuglu, Mehmet Ibrahim ^{[4
]}

Selcuki, Mehmet ^{[1
]}

机构：

[1] Celal Bayar Univ, Dept Neurosurg, Sch Med, Yelken Evleri Sitesi B Blok K 5 D 16 Guzelyurt, Manisa, Turkey

[2] Celal Bayar Univ, Fac Sci, Dept Biol, Manisa, Turkey

[3] Celal Bayar Univ, Letters Zool Sect, Manisa, Turkey

[4] Celal Bayar Univ, Dept Histol Embryol, Sch Med, Manisa, Turkey

来源：

CHILDS NERVOUS SYSTEM | 2016年 / 32卷 / 09期

关键词：

Anti-epileptic; Chick embryo; Lacosamide; Malformation; PREGNANCY; SEIZURES; EPILEPSY; DEFECTS; IMPACT;

D O I：

10.1007/s00381-016-3181-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study, three different doses of LCM (0.12, 0.5, and 1.60 mg in 0.18 mL) were applied under the embryonic disks of specific pathogen-free Leghorn chicken embryos after a 30-h incubation. Incubation was continued for 80 h, at which time all embryos were evaluated macroscopically and microscopically. There was growth retardation in all of the LCM-treated groups. Major malformations increased in a dose-dependent manner and were mostly observed in the supratherapeutic group. Based on our data, LCM may cause growth retardation or major congenital malformations. Nevertheless, more extensive investigations of its reliability are needed.

引用

页码：1715 / 1719

页数：5

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