Radiofrequency ablation for primary hyperparathyroidism and risk factors for postablative eucalcemic parathyroid hormone elevation

被引:12
|
作者
Peng, Cheng-Zhong [1 ,2 ,3 ,4 ]
Chai, Hui-Hui [5 ]
Zhang, Zheng-Xian [6 ]
Hu, Qiao-Hong [7 ]
Zeng, Zeng [7 ]
Cui, Ai-Lin [7 ]
Pang, Hai-Su [6 ]
Ruan, Li-Tao [1 ]
机构
[1] Xi An Jiao Tong Univ, Dept Ultrasound, Affiliated Hosp 1, Xian, Peoples R China
[2] Shanghai Tenth Peoples Hosp, Dept Med Ultrasound, Shanghai, Peoples R China
[3] Tongji Univ, Clin Res Ctr Intervent Med, Ultrasound Res & Educ Inst, Sch Med, Shanghai, Peoples R China
[4] Shanghai Engn Res Ctr Ultrasound Diag & Treatment, Shanghai, Peoples R China
[5] Bengbu Med Coll, Grad Dept, Bengbu, Peoples R China
[6] Hangzhou Hosp Tradit Chinese Med, Dept Ultrasound, Hangzhou, Peoples R China
[7] Zhejiang Prov Peoples Hosp, Peoples Hosp, Dept Ultrasound, Hangzhou Med Coll, Hangzhou, Peoples R China
关键词
Primary hyperparathyroidism; intact parathyroid hormone; parathyroid glands; radiofrequency ablation; eucalcemic parathyroid hormone elevation; MICROWAVE ABLATION; SERUM LEVELS; FOLLOW-UP; PERSISTENT; SURGERY; ADENOMA; GUIDELINES; MANAGEMENT; EFFICACY; CALCIUM;
D O I
10.1080/02656736.2022.2047231
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective To investigate the efficacy of radiofrequency ablation (RFA) as a treatment option for primary hyperparathyroidism (pHPT) and risk factors for postablative eucalcemic parathyroid hormone elevation (ePTH). Methods This retrospective study included 51 patients with pHPT who underwent RFA. The patients were divided into the ePTH and normal PTH groups, based on the serum intact parathyroid hormone (iPTH) level one month after ablation. Serum iPTH, calcium, and phosphorus levels, and the volume reduction rates (VRR) of the parathyroid glands were compared between the groups at each follow-up point. Risk factors for ePTH at one month after ablation were examined. Results After RFA, one (2%) patient had persistent pHPT, and 50 (98%) patients were cured. The incidence rates of ePTH at 1, 3, 6, and 12 months were 48%, 30%, 20%, and 16%, respectively. Serum iPTH levels in the ePTH group were higher than those in the normal PTH group at each follow-up point (all p < 0.05), except 1 day after ablation (p > 0.05). Serum calcium and phosphorus levels, and the VRR of the glands were comparable in both groups at each follow-up point (all p > 0.05), except for calcium levels 3 days after RFA (p < 0.05). Baseline iPTH (odds ratio, 1.067; p = 0.045) and calcium (odds ratio, 3.923; p = 0.038) levels were independent risk factors for ePTH 1 month after RFA. Conclusions RFA is safe and effective for the treatment of pHPT. Moreover, ePTH occurrence after RFA was associated with baseline iPTH and calcium levels and did not increase the risk of recurrent pHPT.
引用
收藏
页码:490 / 496
页数:7
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