Proton Pump Inhibitors Accelerate Endothelial Senescence

被引：104

作者：

Yepuri, Gautham ^{[1
]}

Sukhovershin, Roman ^{[1
]}

Nazari-Shafti, Timo Z. ^{[1
]}

Petrascheck, Michael ^{[2
]}

Ghebre, Yohannes T. ^{[3
]}

Cooke, John P. ^{[1
]}

机构：

[1] Houston Methodist Res Inst, Dept Chem Physiol Mol & Expt Med, 6670 Bertner Ave,Mail Stop R10 South, Houston, TX 77030 USA

[2] Scripps Res Inst, Dept Chem Physiol Mol & Expt Med, La Jolla, CA 92037 USA

[3] Baylor Coll Med, Dept Radiat Oncol, One Baylor Plaza, Houston, TX 77030 USA

来源：

CIRCULATION RESEARCH | 2016年 / 118卷 / 12期

关键词：

aging; cardiovascular diseases; proteostasis deficiencies; proton pump inhibitors; MOLECULAR-MECHANISMS; NITRIC-OXIDE; L-ARGININE; CELLS; DISEASE; ANGIOGENESIS; PROTEOSTASIS; INFLAMMATION; DYSFUNCTION; TELOMERES;

D O I：

10.1161/CIRCRESAHA.116.308807

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction. Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. Conclusions: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.

引用

页码：E36 / +

页数：27

共 50 条

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[J]. CIRCULATION RESEARCH, 2016, 119 (02) : E31 - E32
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