Dorsomorphin Promotes Human Embryonic Stem Cell Self-Renewal

被引：8
|
作者：
Gonzalez, Rodolfo [1 ]
Lee, Jae Wook [1 ]
Snyder, Evan Y. [2 ]
Schultz, Peter G. [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 15期
关键词：
heterocycles; high-throughput screening; self-renewal; stem cells; PLURIPOTENCY; SURVIVAL; GROWTH;
D O I：
10.1002/anie.201005659
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Self-renewal promoter: Using a high-throughput screening assay, the small molecule dorsomorphin (see scheme) was identified as a positive regulator of human embryonic stem cell (hESC) self-renewal. It is shown that dorsomorphin promotes hESC self-renewal by antagonizing autocrine BMP signaling. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3439 / 3441
页数：3
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