Liver Failure Caused by Light Chain Deposition Disease Associated with Multiple Myeloma

被引：5

作者：

Mena-Duran, Armando ^{[1
]}

Munoz Vicente, Elia

Pareja Llorens, Gonzalo

Sanchis Cervera, Jose ^{[1
]}

机构：

[1] Catholic Univ Valencia, La Plana Hosp, Dept Hematol, Valencia, Spain

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 07期

关键词：

multiple myeloma; immunoglobulin light chains; liver failure; HEPATIC-FAILURE; CELL INFILTRATION; AMYLOIDOSIS; INVOLVEMENT;

D O I：

10.2169/internalmedicine.51.6510

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute liver failure is an unusual complication in multiple myeloma. Here, we report a case of multiple myeloma with light chain deposition disease (LCDD) that presented with progressive jaundice due to intrahepatic cholestasis. Diagnosis was made after liver biopsy that showed deposition of kappa light chains occupying perisinusoidal spaces. The patient developed encephalopathy and liver failure and died despite prompt initiation of dexamethasone therapy. The current prognosis of multiple myeloma patients with liver failure due to LCDD is dismal. New therapeutic strategies might improve this condition.

引用

页码：773 / 776

页数：4

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