EFFECTIVENESS OF TRANSFUSION OF PACKED RED BLOOD CELLS AND WHOLE BLOOD WITH VARIOUS TERMS OF STORAGE TO DOGS

Considering the morphological, biochemical and biomechanical changes of erythrocytes of whole blood and packed red blood cells erythrocyte mass during storage, a standard on the duration of storage of these blood products is required. The aim of the study was to determine and compare the efficacy and safety of transfusion of stored whole blood and packed red blood cells in dogs with anaemia. The studies were conducted at the Department of Therapy and Clinical Diagnostics of the National University of Life and Environmental Sciences of Ukraine and at the "Zoolux" Veterinary Clinic, Kyiv. In total, 37 whole blood bags and 47 packed red blood cells were used in the study. The recipients received transfusions of whole blood and erythrocyte mass immediately after collection and after different storage periods (1-7; 7-14; 14-21; 21-28 days). The recipients monitored the dynamics of haematocrit, lactate, and the development of post-transfusion complications. Transfusion of packed red blood cells and whole blood stored for more than 14 days is less effective in increasing haematocrit in recipients. Haematocrit increase with transfusion of canine fresh whole blood and packed red blood cells is 9.4 +/- 0.98% and 10.2 +/- 0.54% respectively. However, haematocrit with whole blood transfusion and packed red blood cells stored for 14-21 days increased by 5.2 +/- 0.9% and 6.7 +/- 0.98% respectively. The level of lactate in the blood of recipient dogs tends to decrease in case of packed red blood cells transfusion stored till 21 days and canine whole blood stored till 14 days (-1.5 +/- 0.29 mmol/L and -0.7 +/- 0.20 mmol/L, respectively). After the 21st day of storage of blood products, there was a significant increase in the incidence of complications both in animals that were transfused with whole blood (60%) and in those that were transfused with packed red blood cells (42.8%).