Targeting tumor microenvironment with selective small-molecule inhibitors of CDK8/19

被引：1
|
作者：
Porter, Donald C. [1 ]
Chen, Mengqian [2 ]
Liang, Jiaxin [2 ]
Kaza, Vimala [1 ]
Chumanevich, Alexander [1 ]
Altilia, Serena [1 ]
Farmaki, Elena [3 ]
Pena, Marj [2 ]
Schools, Gary P. [2 ]
Chatzistamou, Ioulia [3 ]
Friedhoff, Lawrence T. [1 ]
Wentland, Mark P. [4 ]
Broude, Eugenia V. [2 ]
Kiaris, Hippokratis [3 ]
Roninson, Igor B. [2 ]
机构：
[1] Senex Biotechnol Inc, Columbia, SC USA
[2] Univ S Carolina, Columbia, SC 29208 USA
[3] Univ Athens, Athens, Greece
[4] Rensselaer Polytech Inst, Troy, NY USA
来源：
CANCER RESEARCH | 2015年 / 75卷 / 01期
关键词：
D O I：
10.1158/1538-7445.CHTME14-PR08
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PR08
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Targeting Tumor Microenvironment by Small-Molecule Inhibitors
    Zhong, Shangwei
    Jeong, Ji-Hak
    Chen, Zhikang
    Chen, Zihua
    Luo, Jun-Li
    [J]. TRANSLATIONAL ONCOLOGY, 2020, 13 (01): : 57 - 69
  • [2] Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of Cancer
    Li, Yangguang
    Liu, Yingtao
    Wu, Jianping
    Liu, Xiaosong
    Wang, Lin
    Wang, Ju
    Yu, Jiaojiao
    Qi, Hongyun
    Qin, Luoheng
    Ding, Xiao
    Ren, Feng
    Zhavoronkov, Alex
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (08) : 5439 - 5452
  • [3] Targeting the seed and the soil of cancers with selective small-molecule inhibitors of CDK8/19: Chemopotentiating, chemopreventive, anti-invasive and anti-metastatic activities
    Porter, Donald C.
    Liang, Jiaxin
    Kaza, Vimala
    Chumanevich, Alexander A.
    Altilia, Serena
    Farmaki, Elena
    Chen, Mengqian
    Schools, Gary P.
    Chatzistamou, Ioulia
    Pena, Marj M.
    Friedhoff, Lawrence T.
    Wentland, Mark P.
    Broude, Eugenia
    Kiaris, Hippokratis
    Roninson, Igor B.
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [4] Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
    Mallinger, Aurelie
    Schiemann, Kai
    Rink, Christian
    Stieber, Frank
    Calderini, Michel
    Crumpler, Simon
    Stubbs, Mark
    Adeniji-Popoola, Olajumoke
    Poeschke, Oliver
    Busch, Michael
    Czodrowski, Paul
    Musil, Djordje
    Schwarz, Daniel
    Ortiz-Ruiz, Maria-Jesus
    Schneider, Richard
    Thai, Ching
    Valenti, Melanie
    Brandon, Alexis de Haven
    Burke, Rosemary
    Workman, Paul
    Dale, Trevor
    Wienke, Dirk
    Clarke, Paul A.
    Esdar, Christina
    Raynaud, Florence I.
    Eccles, Suzanne A.
    Rohdich, Felix
    Blagg, Julian
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (03) : 1078 - 1101
  • [5] Novel potent and selective orally available CDK8/19 kinase inhibitors
    Aparicio, Carmen Blanco
    Renner, Oliver
    Gomez-Casero, Elena
    Albarran, Maria Isabel
    Cebria, Antonio
    Barrera, Borja
    Aguirre, Enara
    de Miguel, Maria del Carmen Rodriguez
    Urbana, Manuel
    Hernandez, Ana Isabel
    de la Oliva, Cristina Gomez
    Rivero, Virginia
    Riesco, Rosario Concepcion
    Gonzalez, Sonia Martinez
    Pastor, Joaquin
    [J]. CANCER RESEARCH, 2016, 76
  • [6] Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells
    Johannessen, Liv
    Sundberg, Thomas B.
    O'Connell, Daniel J.
    Kolde, Raivo
    Berstler, James
    Billings, Katelyn J.
    Khor, Bernard
    Seashore-Ludlow, Brinton
    Fassl, Anne
    Russell, Caitlin N.
    Latorre, Isabel J.
    Jiang, Baishan
    Graham, Daniel B.
    Perez, Jose R.
    Sicinski, Piotr
    Phillips, Andrew J.
    Schreiber, Stuart L.
    Gray, Nathanael S.
    Shamji, Alykhan F.
    Xavier, Ramnik J.
    [J]. NATURE CHEMICAL BIOLOGY, 2017, 13 (10) : 1102 - +
  • [7] Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells
    Liv Johannessen
    Thomas B Sundberg
    Daniel J O'Connell
    Raivo Kolde
    James Berstler
    Katelyn J Billings
    Bernard Khor
    Brinton Seashore-Ludlow
    Anne Fassl
    Caitlin N Russell
    Isabel J Latorre
    Baishan Jiang
    Daniel B Graham
    Jose R Perez
    Piotr Sicinski
    Andrew J Phillips
    Stuart L Schreiber
    Nathanael S Gray
    Alykhan F Shamji
    Ramnik J Xavier
    [J]. Nature Chemical Biology, 2017, 13 : 1102 - 1108
  • [8] Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance
    Hofmann, Marco H.
    Mani, Rajeswaran
    Engelhardt, Harald
    Impagnatiello, Maria A.
    Carotta, Sebastian
    Kerenyi, Marc
    Lorenzo-Herrero, Seila
    Boettcher, Jark
    Scharn, Dirk
    Arnhof, Heribert
    Zoephel, Andreas
    Schnitzer, Renate
    Gerstberger, Thomas
    Sanderson, Michael P.
    Rajgolikar, Girish
    Goswami, Swagata
    Vasu, Sumithira
    Ettmayer, Peter
    Gonzalez, Segundo
    Pearson, Mark
    McConnell, Darryl B.
    Kraut, Norbert
    Muthusamy, Natarajan
    Moll, Juergen
    [J]. MOLECULAR CANCER THERAPEUTICS, 2020, 19 (04) : 1018 - 1030
  • [9] CDK8/19 inhibitors: 3-benzylindazoles
    Schiemann, Kai
    Mallinger, Aurelie
    Wienke, Dirk
    Esdar, Christina
    Poeschke, Oliver
    Busch, Michael
    Rohdich, Felix
    Eccles, Suzanne
    Schneider, Richard
    Raynaud, Florence
    Czodrowski, Paul
    Musil, Djordje
    Schwarz, Daniel
    Urbahns, Klaus
    Blagg, Julian
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [10] Development of Selective CDK8 Inhibitors for Colorectal Cancer Treatment
    Brzozka, K.
    Zarebski, A.
    Windak, R.
    Krawczynska, K.
    Klosowska, A.
    Dreas, A.
    Fogt, J.
    Cholody, M.
    Milik, M.
    Rzymski, T.
    [J]. EUROPEAN JOURNAL OF CANCER, 2012, 48 : 159 - 160
12345