Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria

被引：15

作者：

Kwambana-Adams, Brenda A. ^{[1
]}

Amaza, Rahab C. ^{[2
]}

Okoi, Catherine ^{[1
]}

Rabiu, Murtala ^{[3
]}

Worwui, Archibald ^{[1
]}

Foster-Nyarko, Ebenezer ^{[1
]}

Ebruke, Bernard ^{[1
]}

Sesay, Abdul K. ^{[1
]}

Senghore, Madikay ^{[1
]}

Umar, Abdullahi S. ^{[4
]}

Usman, Rabi ^{[4
]}

Atiku, Adamu ^{[4
]}

Abdullahi, Garba ^{[2
]}

Buhari, Yahaya ^{[3
]}

Sani, Rabiu ^{[3
]}

Bako, Husaini U. ^{[3
]}

Abdullahi, Bashir ^{[3
]}

Yarima, Alliyu, I ^{[3
]}

Sikiru, Badaru ^{[2
]}

Moses, Aderinola Olaolu ^{[2
]}

Popoola, Michael O. ^{[2
]}

Ekeng, Eme ^{[2
]}

Olayinka, Adebola ^{[2
]}

Mba, Nwando ^{[2
]}

Kankia, Adamu ^{[6
]}

Mamadu, Ibrahim N. ^{[6
]}

Okudo, Ifeanyi ^{[6
]}

Stephen, Mary ^{[6
]}

Ronveaux, Olivier ^{[7
]}

Busuttil, Jason ^{[8
]}

Mwenda, Jason M. ^{[9
]}

Abdulaziz, Mohammed ^{[5
]}

Gummi, Sulaiman A. ^{[4
]}

Adedeji, Adebayo ^{[2
]}

Bita, Andre ^{[10
]}

Omar, Linda ^{[9
]}

Djingarey, Mamoudou Harouna ^{[9
]}

Alemu, Wondimagegnehu ^{[6
]}

D'Alessandro, Umberto ^{[11
]}

Ihekweazu, Chikwe ^{[2
]}

Antonio, Martin ^{[1
,12
]}

机构：

[1] London Sch Hyg & Trop Med, Med Res Council Unit Gambia, Collaborating Ctr New Vaccines Surveillance, WHO, Atlantic Blvd,POB 273, Banjul, Gambia

[2] Nigeria Ctr Dis Control, Abuja, Nigeria

[3] Ahmad SaniYariman Bakura Specialist Hosp Gusau, Gusau, Zamfara State, Nigeria

[4] Zamfara State Minist Hlth, Gusau, Nigeria

[5] Africa Ctr Dis Control & Prevent, Addis Ababa, Ethiopia

[6] WHO, Country Off Nigeria, Abuja, Nigeria

[7] WHO, Geneva, Switzerland

[8] Publ Hlth England, UK Publ Hlth Rapid Support Team, Salisbury, Wilts, England

[9] WHO, Reg off Africa, Brazzaville, Rep Congo

[10] World Hlth Org Intercountry Support Teams West Af, Ouagadougou, Burkina Faso

[11] London Sch Hyg & Trop Med, Med Res Council Unit Gambia, Dis Control & Eliminat Theme, Atlantic Blvd,POB 273, Banjul, Gambia

[12] Univ Warwick, Warwick Med Sch, Div Microbiol & Immun, Coventry, W Midlands, England

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

DETERMINING CAPSULAR SEROTYPES; SEQUENTIAL MULTIPLEX PCR; STREPTOCOCCUS-PNEUMONIAE; PNEUMOCOCCAL MENINGITIS; GROUP-A; EPIDEMIC; DISEASE; SURVEILLANCE; AFRICA; VACCINE;

D O I：

10.1038/s41598-018-32475-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21(st) Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5-14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5-9 years was 10%, double that reported among adults >= 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.

引用

页数：10

共 11 条

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Brenda A. Kwambana-Adams
Rahab C. Amaza
Catherine Okoi
Murtala Rabiu
Archibald Worwui
Ebenezer Foster-Nyarko
Bernard Ebruke
Abdul K. Sesay
Madikay Senghore
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Rabi Usman
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