Microvascular damage following experimental sinus-vein thrombosis in rats

被引：21
|
作者：
Vosko, MR
Röther, J
Friedl, B
Bültemeier, G
Kloss, CUA
Hamann, GF
机构：
[1] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany
[2] Comenius Univ, Dept Neurol, Jessenius Med Fac, Martin, Slovakia
[3] Univ Hamburg, Hosp Eppendorf, Dept Neurol, D-20246 Hamburg, Germany
来源：
ACTA NEUROPATHOLOGICA | 2003年 / 106卷 / 05期
关键词：
brain infarct; basal lamina damage; immunohistochemistry;
D O I：
10.1007/s00401-003-0755-5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We evaluated effects of thrombosis of the superior sagittal sinus, its bridging and cortical veins (SVT) on the cerebral microvasculature in rats. Cryosections of brains (n=7) were examined for venous infarction and microvascular basal lamina damage 3 h after SVT by immunohistochemical staining of microtubule-associated protein 2 and collagen type IV. Microvessels in the infarctions showed a decrease in the number (23.5 +/- 6.1%, P<0.002) and the total area (24.9 +/- 6.5%, P<0.011) of collagen type IV-positive vessels in contrast to control areas (21.7 +/- 12.4% P<0.007; and 26.3 +/- 15.1 %, P<0.026 in contrast to control areas of unoperated animals). This study showed a significant alteration of the cerebral microvasculature in SVT, which might contribute to edema and hemorrhagic transformation.
引用
收藏
页码：501 / 505
页数：5
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