Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar-Cases Series and a Review of the Literature

被引：5

作者：

Sobas, Marta ^{[1
]}

Podolak-Dawidziak, Maria ^{[1
]}

Lewandowski, Krzysztof ^{[2
]}

Bator, Michal ^{[1
]}

Wrobel, Tomasz ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Hematol Blood Neoplasms & Bone Marrow Transp, Pasteura 4, PL-50367 Wroclaw, Poland

[2] Univ Med Sci, Hematol & Bone Marrow Transplantat Dept, PL-60569 Poznan, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 20期

关键词：

immune thrombocytopenic purpura; essential thrombocythemia; platelet oscillation; POLYCYTHEMIA-VERA; CHRONIC INFLAMMATION; CLONAL HEMATOPOIESIS; JAK2V617F MUTATION; OXIDATIVE STRESS; INCREASED RISK; T-CELLS; THROMBOPOIETIN; RECEPTOR; MYELOFIBROSIS;

D O I：

10.3390/ijms222010918

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article collects several published cases in which immune thrombocytopenic purpura (ITP) is followed by essential thrombocythemia (ET) and vice versa. This surprising clinical condition is possible, but very rare and difficult to diagnose and manage. We have made an attempt to analyse the possible causes of the sequential appearance of ITP and ET taking into consideration the following: alteration of the thrombopoietin (TPO) receptor, the role of autoimmunity and inflammation, and cytokine modulation. A better understanding of these interactions may provide opportunities to determine predisposing factors and aid in finding new treatment modalities both for ITP and ET patients.

引用

页数：13