Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

被引：23
|
作者：
Xue, Busheng [1 ]
Zhao, Jiansong [1 ]
Feng, Penghui [2 ]
Xing, Jia [3 ]
Wu, Hongliang [1 ]
Li, Yan [1 ]
机构：
[1] China Med Univ, Shengjing Hosp, Dept Spine & Joint Surg, 36 Sanhao St, Shenyang 110004, Peoples R China
[2] China Med Univ, Dept Obstet & Gynecol, Reprod Med Ctr, Shengjing Hosp, Shenyang, Peoples R China
[3] China Med Univ, Dept Histol & Embryol, Basic Med Coll, Shenyang, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2019年 / 12卷
基金：
中国国家自然科学基金;
关键词：
UHRF1 protein complex; epigenetic modification; ICBP90; RING FINGER DOMAINS; LYSINE METHYLTRANSFERASE G9A; HEMI-METHYLATED DNA; HISTONE H3 TAIL; CELL-PROLIFERATION; UBIQUITIN-LIKE; BLADDER-CANCER; SRA DOMAIN; REPLICATION MACHINERY; STRUCTURAL INSIGHT;
D O I：
10.2147/OTT.S192234
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypo-methylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study.
引用
收藏
页码：549 / 559
页数：11
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