Synthesis and cytotoxic activity of new peptides containing basic amino acid residues

被引:0
|
作者
Chillemi, F
Francescato, P
Fraccari, A
Galatulas, I
机构
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] Dipartimento Farmacol & Tossicol Med, I-20129 Milan, Italy
关键词
cytotoxicity; HeLa cells; basic peptides; synthesis;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In search of more potent compounds endowed with a cytotoxic activity, a new series of basic peptides was synthesized using solid-phase methods. All peptides were purified by preparative reverse-phase HPLC and characterized by electrospray mass spectrometry. The cytotoxic activity was determined in cultured HeLa cells. The hexadecapeptides 5 and 6 showed a 50% inhibition at the concentration of 30 mu g/ml. The salmina and the polyamino acids of L-arginine, L-histidine and L-lysine, containing sixteen residues, were virtually inactive. This demonstrates that a specific peptide sequence is necessary to obtain a positive response in HeLa test.
引用
收藏
页码:757 / 758
页数:2
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