Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila

被引：5
|
作者：
Oda, Yukiko [2 ]
Yui, Ryoko [1 ]
Sakamoto, Kimitoshi [3 ]
Kita, Kiyoshi [3 ]
Matsuura, Etsuko T. [1 ]
机构：
[1] Ochanomizu Univ, Div Nat Appl Sci, Bunkyo Ku, Tokyo 1128610, Japan
[2] Ochanomizu Univ, Dept Mol Biol & Biochem, Bunkyo Ku, Tokyo 1128610, Japan
[3] Univ Tokyo, Dept Biomed Chem, Bunkyo Ku, Tokyo 1130033, Japan
来源：
MITOCHONDRION | 2012年 / 12卷 / 02期
关键词：
Drosophila; Aging; Mitochondria; Electron transport chain activity; Mitochondrial morphology; HUMAN SKELETAL-MUSCLE; CAENORHABDITIS-ELEGANS; ELECTRON-TRANSPORT; NADH DEHYDROGENASE; OXIDATIVE STRESS; LIFE-SPAN; MELANOGASTER; SUPEROXIDE; SUBUNIT; DECLINE;
D O I：
10.1016/j.mito.2012.01.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Using Drosophila melanogaster, we examined changes in the activities of some of the respiratory enzyme complexes with age. The age-related decreases of enzyme activities were observed especially in complex I. We also examined changes in the ultrastructure of mitochondria in the flight muscles of thoraces. The results indicated that the mitochondrial size varied more widely in aged flies than in young ones, in addition to the slight increase in the average size with age. These changes had already appeared before the survival began to decrease, clearly indicating that the accumulation of such changes seriously damages mitochondrial function. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码：345 / 351
页数：7
相关论文
共 50 条
  • [1] Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse
    Kwong, LK
    Sohal, RS
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 373 (01) : 16 - 22
  • [2] Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes
    Chretien, D
    Gallego, J
    Barrientos, A
    Casademont, J
    Cardellach, F
    Munnich, A
    Rötig, A
    Rustin, P
    [J]. BIOCHEMICAL JOURNAL, 1998, 329 : 249 - 254
  • [3] ENZYMATIC-ACTIVITIES OF MITOCHONDRIAL RESPIRATORY COMPLEXES FROM CHILDREN MUSCULAR BIOPSIES - AGE-RELATED EVOLUTIONS
    LEFAI, E
    TERRIERCAYRE, A
    VINCENT, A
    BOESPFLUGTANGUY, O
    TANGUY, A
    ALZIARI, S
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1995, 1228 (01): : 43 - 50
  • [4] Age-related behavioral changes in Drosophila
    Iliadi, Konstantin G.
    Boulianne, Gabrielle L.
    [J]. AGING, CANCER, AND AGE-RELATED DISEASES: COMMON MECHANISM?, 2010, 1197 : 9 - 18
  • [5] Decreased activities of mitochondrial respiratory chain complexes in non-mitochondrial respiratory chain diseases
    Hui, J
    Kirby, DM
    Thorburn, DR
    Boneh, A
    [J]. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2006, 48 (02): : 132 - 136
  • [6] Age-related changes on the morphology of the otoconia
    Jang, Yoon Seok
    Hwang, Chan Ho
    Shin, Ji Young
    Bae, Woo Yang
    Kim, Lee Suk
    [J]. LARYNGOSCOPE, 2006, 116 (06): : 996 - 1001
  • [7] Age-related changes in human respiratory mucosa
    Schroedter, S
    Biermann, E
    Halata, Z
    [J]. FASEB JOURNAL, 2002, 16 (04): : A359 - A359
  • [8] Lack of age-related respiratory changes in Daphnia
    Anderson, Cora E.
    Ekwudo, Millicent N.
    Jonas-Closs, Rachael A.
    Cho, Yongmin
    Peshkin, Leonid
    Kirschner, Marc W.
    Yampolsky, Lev Y.
    [J]. BIOGERONTOLOGY, 2022, 23 (01) : 85 - 97
  • [9] Lack of age-related respiratory changes in Daphnia
    Cora E. Anderson
    Millicent N. Ekwudo
    Rachael A. Jonas-Closs
    Yongmin Cho
    Leonid Peshkin
    Marc W. Kirschner
    Lev Y. Yampolsky
    [J]. Biogerontology, 2022, 23 : 85 - 97
  • [10] Age-related changes in antioxidant enzyme activities
    Bilgin, R.
    Kurt, N.
    Gulesci, N.
    Cinar, E.
    [J]. FEBS JOURNAL, 2015, 282 : 307 - 307
12345