Highly enantioselective amination of? 3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands

被引：1
|
作者：
Bobrova, Angelina Yu. [1 ]
Novikov, Maxim A. [1 ]
Novikov, Roman A. [1 ]
Dorovatovskii, Pavel V. [2 ]
Volodin, Alexander D. [3 ]
Korlyukov, Alexander A. [3 ]
Tomilov, Yury V. [1 ]
机构：
[1] Russian Acad Sci, N D Zelinsky Inst Organ Chem, Moscow 119991, Russia
[2] Kurchatov Inst, Natl Res Ctr, Moscow 123182, Russia
[3] Russian Acad Sci, A N Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia
来源：
MENDELEEV COMMUNICATIONS | 2022年 / 32卷 / 05期
基金：
俄罗斯科学基金会;
关键词：
fluoroalkenes; 2-fluoroallyl amines; enantioselective catalysis; chiral palladium complexes; allylic amination; REDUCTIVE AMINATION;
D O I：
10.1016/j.mencom.2022.09.016
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The key enantioselectivity-determining step in Pd-catalyzed asymmetric amination of 2-fluoroallylic substrates was optimized using model reaction of h3-(2-fluorocycloheptenyl)-palladium complexes bearing chiral P,P-and P,N-ligands with various amines. (S)-ButPHOX was found to be the most effective ligand allowing the formation of 2-fluoroallyl amines and anilines with high enantioselectivity.
引用
收藏
页码：619 / 621
页数：3
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