Increased Expression of the PRL-3 Gene in Human Oral Squamous Cell Carcinoma and Dysplasia Tissues

被引：0

作者：

Hassan, Nur Mohammad Monsur ^{[1
,4
]}

Hamada, Jun-ichi ^{[1
]}

Kameyama, Takeshi ^{[1
]}

Tada, Mitsuhiro ^{[1
]}

Nakagawa, Koji ^{[1
]}

Yoshida, Shoko ^{[4
]}

Kashiwazaki, Haruhiko ^{[2
]}

Yamazaki, Yutaka ^{[3
]}

Suzuki, Yukiko ^{[1
]}

Sasaki, Akira ^{[4
]}

Nagatsuka, Hitoshi ^{[5
]}

Inoue, Nobuo ^{[2
]}

Moriuchi, Tetsuya ^{[1
]}

机构：

[1] Hokkaido Univ, Sch Dent Med, Inst Med Genet, Div Canc Related Genes, Sapporo, Hokkaido, Japan

[2] Hokkaido Univ, Sch Dent Med, Div Geriatr Stomatol, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Sch Dent Med, Dept Oral Pathobiol Sci, Div Oral Diag & Oral Med, Sapporo, Hokkaido, Japan

[4] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral & Maxillofacial Surg, Okayama 7008530, Japan

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Pathol & Med, Okayama 7008530, Japan

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2011年 / 12卷 / 04期

关键词：

PRL; oral squamous carcinoma; dysplasia; p53; PROTEIN-TYROSINE PHOSPHATASES; YEAST FUNCTIONAL ASSAY; P53; TUMOR-SUPPRESSOR; COLORECTAL-CANCER; MUTANT P53; WILD-TYPE; REGENERATING LIVER-3; METASTASIS; MUTATIONS; TARGET;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Phosphatase of regenerating liver (PRL) belongs to a class of the protein tyrosine phosphatase family, which is known so far to consist of 3 members, PRL-1, PRL-2, and PRL-3. The aim of this study was to uncover the role of PRL genes in development of oral malignancy. We analyzed expression levels of the 3 PRL genes in 50 human oral squamous cell carcinomas (OSCCs), 11 dysplasia and 12 normal mucosa tissues by a real-time RTPCR method. PRL-3 but not PRL-1 or PRL-2 expressions were significantly higher in OSCC and dysplasia than in normal mucosa tissues. Additionally, PRL-3 expressions were significantly higher in OSCC tissues harboring dominant-negative p53 or recessive p53 mutation than in those harboring wild-type p53. These results suggest that PRL-3 plays a role in oral cancer development and can be useful as a marker of pre-malignant and malignant lesion of oral mucosa.

引用

页码：947 / 951

页数：5

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