The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma

被引：18
|
作者：
Wang, Kaiting [1 ]
Qiu, Xinyao [2 ]
Zhao, Yan [1 ]
Wang, Hongyang [3 ,4 ]
Chen, Lei [4 ]
机构：
[1] Fudan Univ, Sch Life Sci, Shanghai 200438, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
[3] Fudan Univ, Inst Metab & Integrat Biol IMIB, Shanghai 200438, Peoples R China
[4] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China
来源：
CANCER BIOLOGY & MEDICINE | 2022年 / 19卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Wnt/beta-catenin signaling; HCC; tumor microenvironment; immunotherapy; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; BETA-CATENIN; LIVER; PROGRESSION; NOTCH; ACTIVATION; SORAFENIB; HETEROGENEITY; PROLIFERATION;
D O I：
10.20892/j.issn.2095-3941.2021.0306
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Wnt/beta-catenin signaling pathway regulates many aspects of tumor biology, and many studies have focused on the role of this signaling pathway in tumor cells. However, it is now clear that tumor development and metastasis depend on the two way interaction between cancer cells and their environment, thereby forming a tumor microenvironment (TME). In this review, we discuss how Wnt/beta-catenin signaling regulates cross-interactions among different components of the TME, including immune cells, stem cells, tumor vasculature, and noncellular components of the TME in hepatocellular carcinoma. We also investigate their preclinical and clinical insights for primary liver cancer intervention, and explore the significance of using Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy.
引用
收藏
页码：305 / 318
页数：14
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