Phase I dose escalation trial of nintedanib in combination with pembrolizumab in patients with advanced solid tumors (PEMBIB trial)

被引:0
|
作者
Baldini, C. [1 ]
Danlos, F-X. [2 ]
Varga, A. [1 ]
Halse, H. [3 ]
Mouraud, S. [4 ]
Cassard, L. [5 ,6 ]
Bredel, D. [4 ]
Escriou, G. [4 ]
Parpaleix, A. [7 ]
Rafie, S. [1 ]
Abbassi, A. E. [1 ]
Laghouati, S. [8 ]
Farhane, S. [1 ]
Tselikas, L. [9 ]
Texier, M. [10 ]
Adam, J. [11 ]
Chaput, N. [12 ]
Soria, J-C. [13 ]
Massard, C. [1 ]
Marabelle, A. [14 ]
机构
[1] Gustave Roussy, Drug Dev Dept, Villejuif, France
[2] Gustave Roussy, Drug Dev Dept, INSERM UMR1015, Villejuif, France
[3] Gustave Roussy, INSERM U1163, Imagine Inst, Villejuif, France
[4] Gustave Roussy, INSERM UMR1015, Villejuif, France
[5] Univ Paris Saclay, Gustave Roussy, Lab Immunomonitoring Oncol, CNRS UMS 3655, Villejuif, France
[6] Paris Saclay Univ, Gustave Roussy, INSERM US23, Villejuif, France
[7] Gustave Roussy, Serv Promot Etud Clin, Direct Rech Clin, Villejuif, France
[8] Gustave Roussy, Pharmacovigilance Dept, Villejuif, France
[9] Gustave Roussy Canc Campus, Intervent Radiol, Villejuif, France
[10] Gustave Roussy, Biostat, Villejuif, France
[11] Grp Hosp Paris St Joseph, Dept Pathol, Paris, France
[12] Univ Paris Saclay, UMR9019, Lab Immunomonitoring Oncol,CNRS, Gustave Roussy,Equipe Labellisee Ligue Natl Canc, Villejuif, France
[13] Inst Gustave Roussy, Direct Gen, Villejuif, France
[14] Inst Gustave Roussy, Drug Dev Dept, INSERM, UMR1015, Villejuif, France
关键词
D O I
10.1016/j.annonc.2021.08.1368
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
984P
引用
收藏
页码:S842 / S843
页数:2
相关论文
共 50 条
  • [1] Safety and efficacy results from a phase I dose-escalation trial of Nintedanib in combination with Pembrolizumab in patients with advanced solid tumors (PEMBIB trial).
    Varga, Andreea
    Baldini, Capucine
    Martin-Romano, Patricia
    Besse, Benjamin
    Planchard, David
    Champiat, Stephane
    Angevin, Eroc
    Hollebecque, Antoine
    Bahleda, Rastislav
    Gazzah, Anas
    Armand, Jean-Pierre
    Paoletti, Xavier
    Massard, Christophe
    Soria, Jean-Charles
    Marabelle, Aurelien
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [2] Safety and efficacy results from a phase I dose-escalation trial of Nintedanib in combination with Pembrolizumab in patients with advanced solid tumors (PEMBIB trial)
    Varga, Andreea
    Baldini, Capucine
    Martin-Romano, Patricia
    Hollebecque, Antoine
    Gazzah, Anas
    Bahleda, Rastislav
    Menis, Jessica
    Champiat, Stephane
    El-Dakdouki, Yolla
    Paoletti, Xavier
    Ribrag, Vincent
    Michot, Jean-Marie
    Rafie, Saloomeh
    Planchard, David
    Besse, Benjamin
    Massard, Christophe
    Soria, Jean-Charles
    Marabelle, Aurelien
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [3] Phase I dose escalation trial of pegzilarginase in patients with advanced solid tumors
    Rasco, Drew W.
    Eckhardt, S. Gail
    Davar, Diwakar
    Lewis, Karl
    Lara-Guerra, Humberto
    Alters, Susan E.
    Eckert, Stephen
    Rowlinson, Scott W.
    Wooldridge, James E.
    Carvajal, Richard D.
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [4] Phase I dose escalation trial of biweekly pemetrexed in combination with docetaxel in advanced solid tumors
    Garland, L. L.
    Cranmer, L., III
    Gerstner, G.
    Walker, R.
    Obregon, Y.
    Ebbinghaus, S.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [5] Phase I trial of fruquintinib in patients with advanced solid tumors; Results of the dose escalation phase
    Wang-Gillam, A.
    Yeckes-Rodin, H.
    Kosmo, M. A.
    Stanton, T.
    Park, H.
    Songhua, F.
    Sauter, N. P.
    Kania, M.
    [J]. ANNALS OF ONCOLOGY, 2019, 30 : 175 - +
  • [6] A Phase I, Dose-Escalation Trial of Pazopanib in Combination with Cisplatin in Patients with Advanced Solid Tumors: A UNICANCER Study
    Véronique Diéras
    Thomas Bachelot
    Mario Campone
    Nicolas Isambert
    Florence Joly
    Christophe Le Tourneau
    Philippe Cassier
    Emmanuelle Bompas
    Pierre Fumoleau
    Sabine Noal
    Christine Orsini
    Marta Jimenez
    Diane Charlotte Imbs
    Etienne Chatelut
    [J]. Oncology and Therapy, 2016, 4 (2) : 211 - 223
  • [7] A Phase I, Dose-Escalation Trial of Pazopanib in Combination with Cisplatin in Patients with Advanced Solid Tumors: A UNICANCER Study
    Dieras, Veronique
    Bachelot, Thomas
    Campone, Mario
    Isambert, Nicolas
    Joly, Florence
    Le Tourneau, Christophe
    Cassier, Philippe
    Bompas, Emmanuelle
    Fumoleau, Pierre
    Noal, Sabine
    Orsini, Christine
    Jimenez, Marta
    Imbs, Diane Charlotte
    Chatelut, Etienne
    [J]. ONCOLOGY AND THERAPY, 2016, 4 (02) : 211 - 223
  • [8] A Phase I dose-escalation study of afatinib combined with nintedanib in patients with advanced solid tumors
    Gordon, Michael S.
    Springett, Gregory M.
    Su, Yungpo Bernard
    Ould-Kaci, Mahmoud
    Wind, Sven
    Zhao, Yihua
    LoRusso, Patricia M.
    [J]. FUTURE ONCOLOGY, 2015, 11 (10) : 1479 - 1491
  • [9] Phase 1b trial of nintedanib in combination with bevacizumab in patients with advanced solid tumors
    Ravi Paluri
    Ankit Madan
    Peng Li
    Benjamin Jones
    Mansoor Saleh
    Mary Jerome
    Deborah Miley
    Jennifer Keef
    Francisco Robert
    [J]. Cancer Chemotherapy and Pharmacology, 2019, 83 : 551 - 559
  • [10] Phase 1b trial of nintedanib in combination with bevacizumab in patients with advanced solid tumors
    Paluri, Ravi
    Madan, Ankit
    Li, Peng
    Jones, Benjamin
    Saleh, Mansoor
    Jerome, Mary
    Miley, Deborah
    Keef, Jennifer
    Robert, Francisco
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2019, 83 (03) : 551 - 559