Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke

被引：17
|
作者：
Demyanenko, Svetlana [1 ]
Dzreyan, Valentina [1 ]
Sharifulina, Svetlana [1 ]
机构：
[1] Southern Fed Univ, Acad Biol & Biotechnol, Lab Mol Neurobiol, Pr Stachki 194-1, Rostov Na Donu 344090, Russia
来源：
BIOMEDICINES | 2021年 / 9卷 / 10期
基金：
俄罗斯科学基金会;
关键词：
ischemic stroke; epigenetics; histone deacetylase; histone deacetylase inhibitor; SIRT1-DEPENDENT PGC-1-ALPHA EXPRESSION; FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; BRAIN-DAMAGE; NEURONAL SURVIVAL; HDAC INHIBITORS; SIRTUIN; MITOCHONDRIAL BIOGENESIS; NEURITE OUTGROWTH; CORTICAL-NEURONS;
D O I：
10.3390/biomedicines9101445
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4. Histone deacetylases inhibitors have been shown to be effective in protecting the brain from ischemic damage. Histone deacetylases inhibitors induce neurogenesis and angiogenesis in damaged brain areas promoting functional recovery after cerebral ischemia. However, the role of different histone deacetylases isoforms in the survival and death of brain cells after stroke is still controversial. This review aims to analyze the data on the neuroprotective activity of nonspecific and selective histone deacetylase inhibitors in ischemic stroke.
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页数：20
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