Synthesis of C2-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides

被引：8

作者：

He, Weiping ^{[1
]}

Zhao, Wei ^{[1
]}

Zhou, Bihui ^{[1
,4
]}

Liu, Haifeng ^{[1
]}

Li, Xiangrong ^{[1
]}

Li, Linlin ^{[1
]}

Li, Jie ^{[1
]}

Shi, Jianyou ^{[2
,3
]}

机构：

[1] Zhejiang Univ City Coll, Sch Med, 48 Huzhou Rd, Hangzhou 310015, Zhejiang, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Individualized Medicat Key Lab Sichuan Prov, Chengdu 610072, Peoples R China

[3] Univ Elect Sci & Technol China, Med Informat Ctr, Sch Med, Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R China

[4] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

MOLECULES | 2016年 / 21卷 / 06期

基金：

中国国家自然科学基金;

关键词：

N-heterocyclic carbene; benzimidazolium; Pd-catalyzed; asymmetric intramolecular alpha-arylation; HETEROCYCLIC CARBENE LIGANDS; ASYMMETRIC ALLYLATION; OXINDOLES;

D O I：

10.3390/molecules21060742

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of C-2-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular alpha-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities.

引用

页数：7

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