Noradrenaline-degrading activity of monoamine oxidase is localized in noradrenergic neurons of the locus coeruleus of the rat

被引：1
|
作者：
Hasegawa, Y [1 ]
Hida, T [1 ]
Arai, R [1 ]
机构：
[1] Fujita Hlth Univ, Sch Med, Dept Anat, Aichi 4701192, Japan
来源：
NEUROSCIENCE LETTERS | 1999年 / 264卷 / 1-3期
关键词：
monoamine oxidase; tyrosine hydroxylase; noradrenergic neurons; serotonergic neurons; locus coeruleus; dorsal raphe nucleus;
D O I：
10.1016/S0304-3940(99)00154-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We found intense monoamine oxidase (MAO) activity in rat locus coeruleus (LC) neurons by means of a histochemical method using noradrenaline as a substrate. This MAO activity was abolished by clorgyline, a specific inhibitor of MAO type A. Fluorescence immunohistochemistry for tyrosine hydroxylase (TH) combined with MAO histochemistry revealed intense MAO activity in virtually all TH-immunoreactive LC neurons (i.e. noradrenergic neurons). The results indicate that noradrenaline produced in LC neurons might be degraded by MAO type A activity. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
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页码：61 / 64
页数：4
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