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Efficacy of tamoxifen following anastrozole ('Arimidex') compared with anastrozole following tamoxifen as first-line treatment for advanced breast cancer in postmenopausal women
被引:61
|作者:
Thürlimann, B
[1
]
Robertson, JFR
Nabholtz, JM
Buzdar, A
Bonneterre, J
机构:
[1] Kantonsspital, Senol Ctr Eastern Switzerland, Swiss Grp Clin Canc Res SAKK, CH-9007 St Gallen, Switzerland
[2] City Hosp, Nottingham NG5 1PB, England
[3] Univ Calif Los Angeles, Los Angeles, CA USA
[4] MD Anderson Canc Ctr, Houston, TX USA
[5] Ctr Oscar Lambret, F-59020 Lille, France
关键词:
anastrozole;
tamoxifen;
sequencing;
postmenopausal;
advanced breast cancer;
first-line;
second-line;
D O I:
10.1016/S0959-8049(03)00602-6
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Anastrozole ('Arimidex') is indicated for the treatment of advanced breast cancer in postmenopausal women. Combined analysis of two international randomised, double-blind trials (n = 1021) showed that in patients with hormone receptor-positive tumours, first-line treatment with anastrozole significantly prolonged the time to progression (TTP) compared with tamoxifen (median TTP: 10.7 versus 6.4 months, respectively; P=0.022). Second-line tamoxifen following anastrozole, or vice versa, in this trial population was unblinded. The treatments were crossed over and then efficacy was assessed using a questionnaire. Of 511 patients randomised to anastrozole, 137 (26.8%) received second-line tamoxifen. Questionnaire data were available for 119 patients; 58 (48.7%) gained clinical benefit (CB = complete + partial response (CR + PR) + (stable disease (SD) greater than or equal to 24 weeks)), while 12 (10.1%) had an objective response (OR = CR + PR). Of 510 patients randomised to tamoxifen, 134 (26.3%) received second-line anastrozole. Questionnaire data from 95 patients showed that 54 (56.8%) gained CB and 7 of the patients gaining CB (7.4%) had an OR. Previous studies showed anastrozole is effective after first-line tamoxifen. These data show that the sequential administration of first-line anastrozole followed by tamoxifen provides effective use of these drugs in the treatment of postmenopausal women with advanced breast cancer. (C) 2003 Elsevier Ltd. All rights reserved.
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页码:2310 / 2317
页数:8
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