DNA methylation in mouse embryonic stem cells and development

被引：39
|
作者：
Latham, Tom [1 ]
Gilbert, Nick [1 ]
Ramsahoye, Bernard [1 ]
机构：
[1] Univ Edinburgh, Canc Res Ctr, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
来源：
CELL AND TISSUE RESEARCH | 2008年 / 331卷 / 01期
关键词：
DNA methylation; development; imprinting; chromatin; embryonic stem cells;
D O I：
10.1007/s00441-007-0537-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mammalian development is associated with considerable changes in global DNA methylation levels at times of genomic reprogramming. Normal DNA methylation is essential for development but, despite considerable advances in our understanding of the DNA methyltransferases, the reason that development fails when DNA methylation is deficient remains unclear. Furthermore, although much is known about the enzymes that cause DNA methylation, comparatively little is known about the mechanisms or significance of active demethylation in early development. In this review, we discuss the roles of the various DNA methyltransferases and their likely functions in development.
引用
收藏
页码：31 / 55
页数：25
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