Generation of an induced pluripotent stem cell line SYSUi-003-A from a child with epilepsy carrying GRIN2A mutation

被引：1
|
作者：
Sun, Chuanbo [1 ,2 ]
Yang, Mingzhu [2 ]
Qin, Fengying [1 ]
Guo, Ruirui [2 ]
Liang, Shiqi [2 ]
Hu, Hao [1 ,3 ]
机构：
[1] Guangzhou Med Univ, Guangzhou Inst Pediat, Guangzhou Women & Childrens Med Ctr, Lab Med Syst Biol, Guangzhou 510623, Peoples R China
[2] Sun Yat Sen Univ, Key Lab Stem Cells & Tissue Engn, Dept Histol & Embryol,Zhongshan Sch Med, Ctr Stem Cell Biol & Tissue Engn,Minist Educ, Guangzhou 510275, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 3, Zhengzhou 450052, Peoples R China
来源：
STEM CELL RESEARCH | 2020年 / 43卷
基金：
中国国家自然科学基金;
关键词：
Epilepsy; GRIN2A; human induced pluripotent stem cells;
D O I：
10.1016/j.scr.2020.101706
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
We generated iPSCs from peripheral blood mononuclear cells of a child with epilepsy carrying heterozygous missense mutation in GRIN2A, using integration free episomal vectors. These iPSCs express pluripotent markers, represent a normal karyotype and have the ability to differentiate into three germ layers.
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页数：4
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