In vitro effects of MYCN sense and antisense expression in MYCN-amplified human neuroblastoma cells

被引：0
|
作者：
Kavallaris, M [1 ]
Gardaneh, M [1 ]
Cheung, B [1 ]
Camacho, ML [1 ]
Hocker, JE [1 ]
Norris, MD [1 ]
Haber, M [1 ]
Marshall, GM [1 ]
机构：
[1] Sydney Childrens Hosp, Childrens Canc Res Inst, Randwick, NSW 2031, Australia
来源：
ANTICANCER RESEARCH | 1998年 / 18卷 / 3A期
关键词：
MYCN; neuroblastoma; antisense RNA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Amplification of the MYCN oncogene is a strong predictor of treatment failure and chemo-resistance in childhood neuroblastoma. Stable expression of two partial MYCN gene fragments in antisense orientation reduced Mycn protein expression in an MYCN-amplified neuroblastoma tumor cell line, however; antisense cells did not exhibit an increased in vitro sensitivity to cytotoxic ol differentiating agents. In contrast, partial MYCN sense transfectants exhibited increased resistance to cytotoxic drugs. These data suggest that the chemo-resistance of MYCN-amplified neuroblastoma cells is complex, and may be due to factors additional to Mycn protein expression.
引用
收藏
页码：1793 / 1797
页数：5
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