CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice

被引：18

作者：

Pihlgren, M ^{[1
]}

Tougne, C ^{[1
]}

Schallert, N ^{[1
]}

Bozzotti, P ^{[1
]}

Lambert, PH ^{[1
]}

Siegrist, CA ^{[1
]}

机构：

[1] CMU, World Hlth Organizat Collaborat Ctr Vaccinol & Ne, Dept Pathol & Pediat, CH-1211 Geneva, Switzerland

来源：

VACCINE | 2003年 / 21卷 / 19-20期

关键词：

CpG-motifs; neonatal; antibodies;

D O I：

10.1016/S0264-410X(03)00052-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unmethylated CpG oligonucleotides (CpG-ODN) increase adult and neonatal primary antibody responses to T-dependent antigens, at yet unidentified stages of antigen-specific B cell differentiation. In adult mice, a single dose of CpG-ODN adjuvanted tetanus toxoid (TT) vaccine markedly enhanced and prolonged splenic TT-specific antibody-secreting-cell (ASC) responses and significantly increased the size of the bone marrow (BM) ASC pool. Surprisingly, this was not associated with changes of germinal center (GC) numbers, size, apoptosis or function. In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2492 / 2499

页数：8