Developing an influenza vaccine using lipid nanoparticle-encapsulated nucleoside-modified mRNA

被引：0
|
作者：
Pardi, N. [1 ]
Naradikian, M. S. [1 ]
Parkhouse, K. [2 ]
Hensley, S. E. [2 ]
Cancro, M. P. [1 ]
Weissman, D. [1 ]
机构：
[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[2] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2016年 / 46卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
1349
引用
收藏
页码：1232 / 1233
页数：2
相关论文
共 50 条
  • [1] Transient yet Robust Expression of Proteins in the Mouse Liver via Intravenous Injection of Lipid Nanoparticle-encapsulated Nucleoside-modified mRNA
    Everton, Elissa
    Rizvi, Fatima
    Smith, Anna
    Beattie, Mitchell
    Tam, Ying
    Pardi, Norbert
    Weissman, Drew
    Gouon-Evans, Valerie
    BIO-PROTOCOL, 2021, 11 (19):
  • [2] Organ Specific Induction of Lymphatic Growth with Nanoparticle-Encapsulated Nucleoside-Modified VEGFC mRNA (VEGFC mRNA-LNP) Complexes In Vivo
    Szoke, D.
    Dinnyes, A. Styevkone
    Pardi, N.
    Ajtay, K.
    Weissman, D.
    Jakus, Z.
    JOURNAL OF VASCULAR RESEARCH, 2017, 54 : 31 - 31
  • [3] Developing an Anti-HIV Vaccine Using Nucleoside-Modified mRNA Encoding Envelope
    Pardi, N.
    Kariko, K.
    Conde, A.
    Muramatsu, H.
    Hoxie, J. A.
    Weissman, D.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2013, 29 (11) : A157 - A158
  • [4] Lyophilization provides long-term stability for a lipid nanoparticle-formulated , nucleoside-modified mRNA vaccine
    Muramatsu, Hiromi
    Lam, Kieu
    Bajusz, Csaba
    Laczko, Dorottya
    Kariko, Katalin
    Schreiner, Petra
    Martin, Alan
    Lutwyche, Peter
    Heyes, James
    Pardi, Norbert
    MOLECULAR THERAPY, 2022, 30 (05) : 1941 - 1951
  • [5] A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
    Arevalo, Claudia P.
    Bolton, Marcus J.
    Le Sage, Valerie
    Ye, Naiqing
    Furey, Colleen
    Muramatsu, Hiromi
    Alameh, Mohamad-Gabriel
    Pardi, Norbert
    Drapeau, Elizabeth M.
    Parkhouse, Kaela
    Garretson, Tyler
    Morris, Jeffrey S.
    Moncla, Louise H.
    Tam, Ying K.
    Fan, Steven H. Y.
    Lakdawala, Seema S.
    Weissman, Drew
    Hensley, Scott E.
    SCIENCE, 2022, 378 (6622) : 899 - 904
  • [6] Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA
    Patel, Siddharth
    Ashwanikumar, N.
    Robinson, Emily
    DuRoss, Allison
    Sun, Conroy
    Murphy-Benenato, Kerry E.
    Mihai, Cosmin
    Almarsson, Orn
    Sahay, Gaurav
    NANO LETTERS, 2017, 17 (09) : 5711 - 5718
  • [7] Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses
    Pardi, Norbert
    Carreno, Juan Manuel
    O'Dell, George
    Tan, Jessica
    Bajusz, Csaba
    Muramatsu, Hiromi
    Rijnink, Willemijn
    Strohmeier, Shirin
    Loganathan, Madhumathi
    Bielak, Dominika
    Sung, Molly M. H.
    Tam, Ying K.
    Krammer, Florian
    McMahon, Meagan
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [8] Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses
    Norbert Pardi
    Juan Manuel Carreño
    George O’Dell
    Jessica Tan
    Csaba Bajusz
    Hiromi Muramatsu
    Willemijn Rijnink
    Shirin Strohmeier
    Madhumathi Loganathan
    Dominika Bielak
    Molly M. H. Sung
    Ying K. Tam
    Florian Krammer
    Meagan McMahon
    Nature Communications, 13
  • [9] Assessment of a quadrivalent nucleoside-modified mRNA vaccine that protects against group 2 influenza viruses
    McMahon, Meagan
    O'Dell, George
    Tan, Jessica
    Sarkozy, Andras
    Vadovics, Mate
    Carreno, Juan Manuel
    Puente-Massaguer, Eduard
    Muramatsu, Hiromi
    Bajusz, Csaba
    Rijnink, Willemijn
    Beattie, Mitchell
    Tam, Ying K.
    Roubidoux, Ericka Kirkpatrick
    Francisco, Isabel
    Strohmeier, Shirin
    Kanekiyo, Masaru
    Graham, Barney S.
    Krammer, Florian
    Pardi, Norbert
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (45)
  • [10] Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
    Kevin O. Saunders
    Norbert Pardi
    Robert Parks
    Sampa Santra
    Zekun Mu
    Laura Sutherland
    Richard Scearce
    Maggie Barr
    Amanda Eaton
    Giovanna Hernandez
    Derrick Goodman
    Michael J. Hogan
    Istvan Tombacz
    David N. Gordon
    R. Wes Rountree
    Yunfei Wang
    Mark G. Lewis
    Theodore C. Pierson
    Chris Barbosa
    Ying Tam
    Gary R. Matyas
    Mangala Rao
    Zoltan Beck
    Xiaoying Shen
    Guido Ferrari
    Georgia D. Tomaras
    David C. Montefiori
    Drew Weissman
    Barton F. Haynes
    npj Vaccines, 6
12345