Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53

被引：0
|
作者：
Ramos, YFM
Stad, R
Attema, J
Peltenburg, LTC
van der Eb, AJ
Jochemsen, AG
机构：
[1] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2333 AL Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Ctr Biomed Genet, NL-2333 AL Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Clin Oncol, NL-2333 AL Leiden, Netherlands
来源：
CANCER RESEARCH | 2001年 / 61卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been shown that the Hdmx gene is amplified in a subset of gliomas, but thus far, no data are available on HDMX protein expression in tumor cells. We now report that a significant fraction of tumor cell lines expresses increased HDMX levels compared with normal cells; in general, HDMX expression in these tumor cell lines correlates with the presence of wild-type p53, Analysis of tumor material showed that high HDMX expression is not a result of cell line establishment. Interestingly, several cell lines express alternative, shorter HDMX proteins. These results suggest that deregulated expression of plays a role in carcinogenesis as an alternative way to inactivate p53.
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页码：1839 / 1842
页数：4
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