Receptor activity modifying proteins

被引：157
|
作者：
Sexton, PM [1 ]
Albiston, A
Morfis, M
Tilakaratne, N
机构：
[1] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Dept Pharmacol, Mol Pharmacol Lab, Melbourne, Vic 3010, Australia
来源：
CELLULAR SIGNALLING | 2001年 / 13卷 / 02期
基金：
英国医学研究理事会;
关键词：
receptor activity modifying protein; G protein-coupled receptor; calcitonin receptor-like receptor; calcitonin receptor; calcitonin; amylin; calcitonin gene-related peptide; adrenomedullin;
D O I：
10.1016/S0898-6568(00)00143-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Our understandings of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. a similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current slate of knowledge of the mechanisms underlying RAMP function. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：73 / 83
页数：11
相关论文
共 50 条
  • [1] Receptor Activity Modifying Proteins and Their Potential as Drug Targets
    Wootten, Denise L.
    Simms, John
    Hay, Debbie L.
    Christopoulos, Arthur
    Sexton, Patrick M.
    MEMBRANE PROTEINS AS DRUG TARGETS, 2010, 91 : 53 - +
  • [2] Novel receptor partners and function of receptor activity-modifying proteins
    Christopoulos, A
    Christopoulos, G
    Morfis, M
    Udawela, M
    Laburthe, M
    Couvineau, A
    Kuwasako, K
    Tilakaratne, N
    Sexton, PM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (05) : 3293 - 3297
  • [3] The CGRP receptor subtypes associated with receptor activity-modifying proteins (RAMPs)
    Kuwasako, K
    Cao, YN
    Nagoshi, Y
    Kitamura, K
    Eto, T
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 98P - 98P
  • [4] Adrenomedullin selectivity of calcitonin-like receptor/receptor activity modifying proteins
    Muff, R
    Born, W
    Fischer, JA
    HYPERTENSION RESEARCH, 2003, 26 : S3 - S8
  • [5] Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins
    Hay, Debbie L.
    Walker, Christopher S.
    Gingell, Joseph J.
    Ladds, Graham
    Reynolds, Christopher A.
    Poyner, David R.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2016, 44 : 568 - 573
  • [6] The receptor activity modifying protein family of G protein coupled receptor accessory proteins
    Udawela, M
    Hay, DL
    Sexton, PM
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (03) : 299 - 308
  • [7] Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor
    Armour, SL
    Foord, S
    Kenakin, T
    Chen, WJ
    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1999, 42 (04) : 217 - 224
  • [8] RAMPs (receptor activity modifying proteins) as determinants of GPCR ligand selectivity
    Marshall, FH
    Foord, SM
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 : U82 - U82
  • [9] GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs
    Barbash, Shahar
    Lorenzen, Emily
    Persson, Torbjorn
    Huber, Thomas
    Sakmar, Thomas P.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (45) : 12015 - 12020
  • [10] Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles
    Hay, Debbie L.
    Pioszak, Augen A.
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56, 2016, 56 : 469 - 487
12345