In situ Biomimetic Fabrication and Characterization of Nano-hydroxyapatite/Chitosan Composite Microspheres

被引：0
|
作者：
Li Jian [1 ]
Han Zhi-Jun [1 ]
Wet Yan [1 ]
Niu Lu-Lu [1 ]
Liu Yu [1 ]
Lu Guo-Yun [2 ]
Huang Di [1 ]
机构：
[1] Taiyuan Univ Technol, Coll Mech, Shanxi Key Lab Mat Strength & Struct Impact, Taiyuan 030024, Peoples R China
[2] Taiyuan Univ Technol, Inst Appl Mech & Biomed Engn, Taiyuan 030024, Peoples R China
来源：
JOURNAL OF INORGANIC MATERIALS | 2014年 / 29卷 / 12期
基金：
中国国家自然科学基金;
关键词：
in situ biomimetic; nano-hydroxyapatite; chitosan; composite microspheres; BONE; COATINGS; DELIVERY; SCAFFOLD;
D O I：
暂无
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
To solve the problem that nano-hydroxyapatite (nHA) crystals aggregation and non-uniformly distribution in nano-hydroxyapatite/chitosan (CS) composite microspheres, nHA/CS microspheres were prepared through in situ biomimetic method in water-in-oil (W/O) emulsions. The physical and chemical properties of the composite microspheres were investigated by scanning electronic microscopy (SEM), X-ray energy-dispersive spectroscope (EDS), X-ray diffraction (XRD), fourier transform infrared spectroscope (FTIR) and laser particle size analyzer. The results indicate that the composite microspheres are spherical with average size of 8.62 mu m and disperse uniformly. Moreover, the nHA crystals are dispersed uniformly within composite microspheres and bonded with CS matrix. The composite microspheres have great potential in bone tissue engineering and drug delivery system.
引用
收藏
页码：1327 / 1332
页数：6
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