Structure and Function of the Mitochondrial Ribosome

被引：164

作者：

Greber, Basil J. ^{[1
,2
]}

Ban, Nenad ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Mol Biol & Biophys, Dept Biol, CH-8093 Zurich, Switzerland

[2] Univ Calif Berkeley, Calif Inst Quantitat Biosci QB3, Berkeley, CA 94720 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 | 2016年 / 85卷

关键词：

mitochondrial translation; 39S mitoribosomal subunit; 28S mitoribosomal subunit; antibiotics; ribosome evolution; cryo-electron microscopy; PEPTIDYL TRANSFERASE CENTER; DEATH-ASSOCIATED PROTEIN-3; TRANSFER-RNA; CRYO-EM; CRYSTAL-STRUCTURE; LARGE SUBUNIT; 1555A-GREATER-THAN-G MUTATION; ANTIBIOTIC SUSCEPTIBILITY; BACTERIAL RIBOSOME; BINDING PROTEINS;

D O I：

10.1146/annurev-biochem-060815-014343

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the organelles responsible for energy conversion and adenosine triphosphate production in eukaryotic cells. Throughout evolution, mitoribosomes have become functionally specialized for synthesizing mitochondrial membrane proteins, and this has been accompanied by large changes to their structure and composition. We review recent high-resolution structural data that have provided unprecedented insight into the structure and function of mitoribosomes in mammals and fungi.

引用

页码：103 / 132

页数：30

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