Malaria Parasite Clearance: What Are We Really Measuring?

被引：18

作者：

Khoury, David S. ^{[1
]}

Zaloumis, Sophie G. ^{[2
]}

Grigg, Matthew J. ^{[3
]}

Haque, Ashraful ^{[4
]}

Davenport, Miles P. ^{[1
]}

机构：

[1] UNSW Sydney, Kirby Inst, Sydney, NSW 2052, Australia

[2] Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

[3] Menzies Sch Hlth Res, Darwin, NT, Australia

[4] QIMR Berghofer, Brisbane, Qld, Australia

来源：

TRENDS IN PARASITOLOGY | 2020年 / 36卷 / 05期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

SEVERE FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; ARTEMISININ RESISTANCE; ANTIMALARIAL-DRUGS; OPEN-LABEL; ARTESUNATE-MEFLOQUINE; EX-VIVO; PHARMACOKINETICS; ARTEMETHER; VIABILITY;

D O I：

10.1016/j.pt.2020.02.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires large clinical trials and thus we have identified proxy measures of drug efficacy such as the parasite clearance curve. This is often assumed to measure the rate of drug activity against parasites and is used to predict optimal treatment regimens required to completely clear a blood-stage infection. We discuss evidence that the clearance curve is not measuring the rate of drug killing. This has major implications for how we assess optimal treatment regimens, as well as how we prioritise new drugs in the drug development pipeline.

引用

页码：413 / 426

页数：14

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