Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells

被引：9
|
作者：
Khavinson, VK [1 ]
Bondarev, IE [1 ]
Butyugov, AA [1 ]
机构：
[1] Russian Acad Med Sci, NW Div, St Petersburg Inst Bioregulat & Gerontol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 06期
关键词：
peptide; Epithalon; telomerase; telomeres; fibroblasts;
D O I：
10.1023/A:1025493705728
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.
引用
收藏
页码：590 / 592
页数：3
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