This paper mainly focuses on the spatial-temporal changes of land use/cover of Hangjin power-chemical industry base in Neimenggu based on RS and GIS technology. Using the remote sensing data of 2000 and 2005 and the thematic map, actual land use/cover map of this area is obtained based on spatial cartographic database system, then, spatial-temporal changes of land use/cover of this area are calculated and the land use conversion matrix in five years is made. The results show that from 2000 to 2005 the areas of grassland and water land are decreased, others are increased. In addition, the reason of changes of land use is analyzed; the results can be effectual reference for the sustainable land use in the target area.