Phosphine-Catalyzed Diastereoselective [3+3] Annulation of Morita-Baylis-Hillman Carbonates with C,N-Cyclic Azomethine Imines

被引：9

作者：

Zhang, Lei ^{[1
]}

Yang, Wenjun ^{[1
]}

Zhou, Leijie ^{[1
]}

Liu, Honglei ^{[1
]}

Huang, Jiaxing ^{[1
]}

Xiao, Yumei ^{[1
]}

Guo, Hongchao ^{[1
,2
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China

[2] Guizhou Univ, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Guizhou, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 06期

关键词：

RAUHUT-CURRIER REACTION; ELECTRON-DEFICIENT OLEFINS; DOUBLE-MICHAEL REACTIONS; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; 4+2 CYCLOADDITION; FACILE ACCESS; FUNCTIONALIZED CYCLOPENTENES; ALLENOATES SYNTHESIS; FORMAL SYNTHESES;

D O I：

10.1002/jhet.2958

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, phosphine-catalyzed [3 + 3] annulation of Morita-Baylis-Hillman carbonates with C,N-cyclic azomethine imines has been achieved. The reaction worked smoothly under mild conditions to afford 4,6,7,11b-tetrahydro-1H-pyridazino[6,1-a]isoquinoline derivatives in high yields with good to excellent diastereoselectivities.

引用

页码：3377 / 3388

页数：12

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