The G to A polymorphism at-597 of the interleukin-6 gene is extremely rare in southern Han Chinese

被引：12

作者：

Gao, Shu-Ping ^{[2
]}

Pan, Min ^{[1
]}

Chen, Chu ^{[1
]}

Ge, Li-Jun ^{[2
]}

Jiang, Min-Hui ^{[1
]}

Luan, Hong ^{[2
]}

Zheng, Jin-Guo ^{[3
]}

Deng, Xin-Tao ^{[3
]}

Pan, Hai-Yan ^{[1
]}

Zhu, Jian-Hua ^{[1
]}

机构：

[1] Nantong Univ, Affiliated Hosp, Dept Cardiol, Nantong 226001, Peoples R China

[2] Ningxia Peoples Hosp, Dept Cardiol, Yinchuan 750021, Peoples R China

[3] Xinghua Peoples Hosp, Dept Cardiol, Xinghua 225700, Peoples R China

来源：

CYTOKINE | 2011年 / 55卷 / 01期

关键词：

Interleukin-6; Genetic polymorphism; Chinese; CORONARY-ARTERY-DISEASE; TUMOR-NECROSIS-FACTOR; PROMOTER POLYMORPHISM; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; C POLYMORPHISM; HEALTHY-MEN; IL-6; LEVELS; IL6; GENE; ASSOCIATION;

D O I：

10.1016/j.cyto.2011.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH patients and 194 healthy controls from Jiangsu area (south of China). Individuals all carried the GG wild genotype, no GA or AA genotypes were found. Our results suggest that IL-6-597G/A polymorphism is extremely rare and unlikely to be contributing significantly to disease susceptibility in southern Han Chinese. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1 / 3

页数：3

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