Silicon-based mesoporous photonic crystals: towards single cell optical biosensors

被引：1

作者：

Kilian, Kristopher A. ^{[1
]}

Magenau, Astrid ^{[3
]}

Boecking, Till ^{[1
,2
]}

Gaus, Katharina ^{[3
]}

Gal, Michael ^{[2
]}

Gooding, J. Justin ^{[1
]}

机构：

[1] Univ New South Wales, Dept Chem, Sydney, NSW 2052, Australia

[2] Univ New South Wales, Dept Phys, Sydney, NSW 2052, Australia

[3] Univ New South Wales, Ctr Vasc Res, Sydney, NSW 2052, Australia

来源：

BIOSENSING II | 2009年 / 7397卷

关键词：

Porous silicon; photonic crystal; biosensor; protease; cell culture; POROUS SILICON; EXPRESSION; LIPOPOLYSACCHARIDE; NEURONS; MACROPHAGES; CULTURE; FILTERS;

D O I：

10.1117/12.826133

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mesoporous silicon (PSi) photonic crystals have attracted interest as biosensing transducers owing to their high quality optics and sensitivity in optical characteristics to changes in refractive index. We describe progress our group has made derivatizing PSi towards devices for biology and medicine. PSi rugate filters display a high reflectivity resonant line in the reflectance spectrum. As an example for biosensing, immobilization of peptides and biopolymers within the PSi is demonstrated for detecting protease enzymes. Secretion of matrix metalloproteases from live cells was detected as a blue shift in the photonic resonance within hours, demonstrating the promise of this biosensor.

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页数：8

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