Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae

被引：66
|
作者：
Li, Erwei [2 ]
Tian, Renrong [3 ]
Liu, Shuchun [2 ]
Chen, Xulin [1 ,3 ]
Guo, Liangdong [2 ]
Che, Yongsheng [2 ]
机构：
[1] Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Beijing 100080, Peoples R China
[2] Chinese Acad Sci, Ctr Bioenergy & Ind Biotechnol, Inst Microbiol, Beijing 100080, Peoples R China
[3] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 04期
关键词：
D O I：
10.1021/np700744t
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Pestalotheols A-D (1-4), four new metabolites, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis theae. The structures of these compounds were determined by NMR spectroscopy, and 1 is further confirmed by X-ray crystallography. The absolute configurations of compounds 1 and 3 were assigned by application of the modified Mosher method. Pestalotheol C (3) displayed an inhibitory effect on HIV-1(LAI) replication in C8166 cells with an EC50 value of 16.1 mu M.
引用
收藏
页码：664 / 668
页数：5
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