Current challenges in reliably targeting the noradrenergic locus coeruleus using transcutaneous auricular vagus nerve stimulation (taVNS)

被引：20
|
作者：
Ludwig, Mareike [1 ,6 ]
Wienke, Christian [6 ]
Betts, Matthew J. [1 ,3 ,6 ]
Zaehle, Tino [2 ,6 ]
Haemmerer, Dorothea [1 ,4 ,5 ,6 ]
机构：
[1] Univ Hosp Magdeburg, Inst Cognit Neurol & Dementia Res, Fac Med, Magdeburg, Germany
[2] Otto v Guericke Univ, Sect Neuropsychol, Dept Neurol, Magdeburg, Germany
[3] Otto Guericke Univ Magdeburg, German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany
[4] UCL, Inst Cognit Neurosci, London, England
[5] Univ Innsbruck, Dept Psychol, Innsbruck, Austria
[6] CBBS Ctr Behav Brain Sci, Magdeburg, Germany
来源：
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2021年 / 236卷
关键词：
Vagus nerve stimulation; Stimulation parameters; Neuromodulation; Noradrenergic system; Locus coeruleus; Neurodegeneration; Cross-species translational approach; ELECTRICAL-STIMULATION; CEREBROSPINAL-FLUID; AUDITORY-CORTEX; PUPIL DIAMETER; BRAIN-STEM; FUNCTIONAL NEUROANATOMY; SELECTIVE PLASTICITY; ALZHEIMERS-DISEASE; INTEGRATIVE THEORY; VAGAL-STIMULATION;
D O I：
10.1016/j.autneu.2021.102900
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Transcutaneous auricular vagus nerve stimulation (taVNS), as a non-invasive brain stimulation technique may influence the locus coeruleus-norepinephrine system (LC-NE system) via modulation of the Vagus Nerve (VN) which projects to the LC. Few human studies exist examining the effects of taVNS on the LC-NE system and studies to date assessing the ability of taVNS to target the LC yield heterogeneous results. The aim of this review is to present an overview of the current challenges in assessing effects of taVNS on LC function and how translational approaches spanning animal and human research can help in this regard. A particular emphasis of the review discusses how the effects of taVNS may be influenced by changes in structure and function of the LCNE system across the human lifespan and in disease.
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页数：16
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