TERT promoter mutation status in sarcomatoid urothelial carcinomas of the upper urinary tract

被引：19

作者：

Wang, Xiaoyan ^{[1
]}

Lopez-Beltran, Antonio ^{[2
]}

Osunkoya, Adeboye O. ^{[3
,4
]}

Wang, Mingsheng ^{[1
]}

Zhang, Shaobo ^{[1
]}

Davidson, Darrell D. ^{[1
]}

Emerson, Robert E. ^{[1
]}

Williamson, Sean R. ^{[5
]}

Tan, Puay-Hoon ^{[6
]}

Kaimakliotis, Hristos Z. ^{[7
]}

Baldridge, Lee Ann ^{[1
]}

MacLennan, Gregory T. ^{[8
]}

Montironi, Rodolfo ^{[9
]}

Cheng, Liang ^{[1
,2
]}

机构：

[1] Indiana Univ Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

[2] Fac Med, Dept Pathol & Surg, Cordoba, Spain

[3] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Dept Urol, Atlanta, GA 30322 USA

[5] Henry Ford Hlth Syst, Dept Pathol & Lab Med, Detroit, MI USA

[6] Singapore Gen Hosp, Dept Pathol, Singapore, Singapore

[7] Indiana Univ Sch Med, Dept Urol, Indianapolis, IN 46202 USA

[8] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[9] Polytech Univ Marche Reg Ancona, Sch Med, Inst Pathol Anat & Histopathol, United Hosp, Ancona, Italy

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 08期

关键词：

biomarkers; bladder; GATA3; sarcomatoid urothelial carcinoma; TERT promoter mutation; upper urinary tract; ureter; SQUAMOUS-CELL CARCINOMA; BLADDER-CANCER; GATA3; EXPRESSION; P63; UROPLAKIN-III; CLINICOPATHOLOGICAL FEATURES; IMMUNOHISTOCHEMICAL PANEL; PAX8; P40; DELTA-NP63; MARKERS;

D O I：

10.2217/fon-2016-0414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To determine TERT promoter mutation status as well as the expression of PAX8, GATA3, p63, p40, p53 and uroplakin III in 17 patients with the upper urinary tract sarcomatoid urothelial carcinoma. Methods & results: TERT C228T mutations were found in six of 17 cases (35%). p53 was expressed in 77% of these tumors. PAX8, GATA3, p40 and uroplakin III are less frequently expressed. Lymph node metastases were present in ten cases (59%). Eight patients (47%), including all three patients with TERT mutation, died of cancer within 2 years after surgery. Conclusion: Sarcomatoid carcinoma of the upper urinary tract is an aggressive tumor and the presence of TERT mutation may portend poor prognosis.

引用

页码：705 / 714

页数：10

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