Protein biomarker analysis by mass spectrometry in patients with rheumatoid arthritis receiving anti-tumor necrosis factor-α antibody therapy

被引：0
|
作者：
Sekigawa, I. [1 ,2 ]
Yanagida, M. [2 ]
Iwabuchi, K. [2 ]
Kaneda, K. [1 ]
Kaneko, H. [1 ]
Takasaki, Y. [3 ]
Jung, G. [4 ]
Sone, S. [5 ]
Tanaka, Y. [4 ]
Ogawa, H. [2 ]
Takamori, K. [2 ,6 ]
机构：
[1] Juntendo Univ, Urayasu Hosp, Dept Internal Med, Chiba 2710021, Japan
[2] Juntendo Univ, Grad Sch Med, Inst Environm & Gender Specif Med, Chiba 2710021, Japan
[3] Juntendo Univ, Sch Med, Dept Rheumatol & Internal Med, Tokyo, Japan
[4] Toray Industries Ltd, New Frontiers Res Labs, Kanagawa, Japan
[5] Toray Industries Ltd, Head Off, Tokyo, Japan
[6] Juntendo Univ, Urayasu Hosp, Dept Dermatol, Chiba 2710021, Japan
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2008年 / 26卷 / 02期
关键词：
rheumatoid arthritis; anti-TNF-alpha antibody; proteomics; mass spectrometry; connective tissue growth factor (CTGF);
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective To investigate the mechanism of action of anti-tumor necrosis factor-alpha (TNF-alpha) antibody in patients with rheumatoid arthritis (RA), we analyzed serum or plasma proteins by mass spectrometry system. Methods Ten RA patients who received treatment with anti-TNF-alpha antibody were studied. Samples obtained before and after therapy were analyzed by a two-dimensional liquid chromatography tandem mass spectrometry (2D LC-MS/MS) system after pretreatment by a recently developed method to remove high molecular weight proteins. Results Using this system, certain proteins were identified after treatment with anti-TNF-a antibody, including proteins related to the TNF-alpha-mediated pathway for nuclear factor kappa B (NF-kappa B) activation and/or to the metabolism (including regeneration) of articular cartilage. Conclusion Our mass spectrometry system. appears to be useful for proteomic analysis. The efficacy of anti-TNF-alpha antibody therapy for RA may be related to various consequence of the inhibition of TNF-alpha activity.
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页码：261 / 267
页数：7
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