The enantioselective total synthesis of a β-carboline alkaloid, (S)-(-)-dichotomine C

被引：36

作者：

Omura, Kana ^{[1
]}

Choshi, Tominari ^{[1
]}

Watanabe, Shiroh ^{[1
]}

Satoh, Yuhsuke ^{[1
]}

Nobuhiro, Junko ^{[1
]}

Hibino, Satoshi ^{[1
]}

机构：

[1] Fukuyama Univ, Fac Pharm & Pharmaceut Sci, Grad Sch Pahrmacy & Pharmaceut Sci, Hiroshima 7290292, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 02期

关键词：

(S)-(-)-dichotomine C; first synthesis; enantioselective synthesis; aza-electrocyclic reaction; microwave; THERMAL ELECTROCYCLIC REACTION;

D O I：

10.1248/cpb.56.237

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first enantioselective synthesis of a beta-carboline alkaloid, dichotomine C, possessing antiallergic effects, was achieved by constructing a beta-carboline framework based on the microwave-assisted thermal electrocyclic reaction of a 1-azahexatriene system, followed by the Sharpless asymmetric dihydroxylation.

引用

页码：237 / 238

页数：2

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