Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

被引：5

作者：

Hassan, Ahmed R. ^{[1
,5
]}

El-Kousy, Salah M. ^{[2
]}

El-Toumy, Sayed A. ^{[3
]}

Frydenyang, Karla ^{[1
]}

Truong Thanh Tung ^{[1
]}

Olsen, Jesper ^{[4
]}

Nielsen, John ^{[1
]}

Christensen, Soren Bragger ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Drug Design & Pharmacol, DK-2100 Copenhagen O, Denmark

[2] Natl Res Ctr, Chem Tannins Dept, Cairo 12622, Egypt

[3] Menoufia Univ, Chem Dept, Shibin Al Kawm 32861, El Menoufia, Egypt

[4] Aarhus Univ, Dept Phys & Astron, DK-8000 Aarhus C, Denmark

[5] Desert Res Ctr, Med & Aromat Plants Dept, Cairo 11753, Egypt

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 10期

关键词：

NATURAL-PRODUCTS; DRUG METFORMIN; TRAMADOL; FLAVONOIDS; PLANTS;

D O I：

10.1021/acs.jnatprod.7b00106

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the C-14 content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-alpha-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

引用

页码：2830 / 2834

页数：5