The carbohydrate ligands on the host embryo mediate intercellular migration of the parasitic wasp embryo

被引：5

作者：

Takahashi-Nakaguchi, Azusa ^{[1
]}

Hiraoka, Tsuyoshi ^{[1
]}

Iwabuchi, Kikuo ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Fuchu, Tokyo 1838509, Japan

来源：

FEBS LETTERS | 2011年 / 585卷 / 14期

关键词：

Fucose; N-linked carbohydrate chain; Parasitoid; Invasion; Cadherin; Copidosoma floridanum; SALIVARY-GLANDS; HIV-1; GP120; GALACTOSYLCERAMIDE GALCER; COPIDOSOMA-FLORIDANUM; POLYEMBRYONIC WASP; DE-CADHERIN; IDENTIFICATION; MECHANISMS; BINDING; ATTACHMENT;

D O I：

10.1016/j.febslet.2011.05.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Invasive stage embryos of the parasitic wasp Copidosoma floridanum transmigrate through the epithelium of phylogenetically distant host embryos in a manner that is similar to mammalian leukocyte infiltration. Host embryonic cells appear to recognize the invading wasp embryo by components on the cell surface. We developed an in vitro wasp entry inhibition assay and found that C-type lectins of the wasp embryo bound to N-linked carbohydrate chains with fucose residues on the surface of host embryo. This is the first report showing a receptor-ligand interaction between heterologous multicellular organisms. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2295 / 2299

页数：5