Early Diagnosis and Screening for Lung Cancer

被引：14

作者：

Kadara, Humam ^{[1
]}

Tran, Linh M. ^{[2
]}

Liu, Bin ^{[2
]}

Vachani, Anil ^{[3
,4
]}

Li, Shuo ^{[5
]}

Sinjab, Ansam ^{[1
]}

Zhou, Xianghong J. ^{[5
]}

Dubinett, Steven M. ^{[2
,5
,6
,7
,8
]}

Krysan, Kostyantyn ^{[2
,8
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA

[2] Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA

[3] Univ Penn, Dept Med, Pulm Allergy & Crit Care Div, Philadelphia, PA 19104 USA

[4] Philadelphia VA Med Ctr, Philadelphia, PA 19104 USA

[5] Univ Calif Los Angeles, Dept Pathol & Lab Med, David Geffen Sch Med, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[8] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2021年 / 11卷 / 09期

关键词：

CIRCULATING TUMOR-CELLS; ATYPICAL ADENOMATOUS HYPERPLASIA; BRONCHIAL EPITHELIAL-CELLS; MESSENGER-RNA; PERIPHERAL-BLOOD; MOUSE MODELS; MOLECULAR CHARACTERIZATION; PROGNOSTIC-SIGNIFICANCE; CLINICAL-SIGNIFICANCE; RESIDUAL DISEASE;

D O I：

10.1101/cshperspect.a037994

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer interception refers to actively blocking the cancer development process by preventing progression of premalignancy to invasive disease. The rate-limiting steps for effective lung cancer interception are the incomplete understanding of the earliest molecular events associated with lung carcinogenesis, the lack of preclinical models of pulmonary premalignancy, and the challenge of developing highly sensitive and specific methods for early detection. Recent advances in cancer interception are facilitated by developments in next-generation sequencing, computational methodologies, as well as the renewed emphasis in precision medicine and immuno-oncology. This review summarizes the current state of knowledge in the areas of molecular abnormalities in lung cancer continuum, preclinical human models of lung cancer pathogenesis, and the advances in early lung cancer diagnostics.

引用

页数：19

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