Somatic mutation (SM) of human immunoglobulin (Ig) heavy chain variable (V) region genes targets complementarity determining regions (CDR) in the absence of antigen (Ag) selection.

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作者
Varade, WS [1 ]
Jones, JA [1 ]
Kingsley, PD [1 ]
Insel, RA [1 ]
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[1] UNIV ROCHESTER,SCH MED & DENT,DEPT PEDIAT,ROCHESTER,NY 14642
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R72 [儿科学];
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100202 ;
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页码:74 / 74
页数:1
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  • [1] IG heavy and light chain variable genes in chronic lymphocytic leukemia exhibit distinct somatic mutation patterns and a comparable imprint of antigen selection.
    Stamatopoulos, K
    Belessi, C
    Hadzidimitriou, A
    Hatzi, K
    Stavroyianni, N
    Kalagiakou, E
    Papadaki, T
    Marantidou, F
    Manioudaki, E
    Athanasiadou, A
    Douka, V
    Athanasiadou, L
    Tachynopoulou, V
    Saloum, R
    Laoutaris, N
    Fassas, A
    Anagnostopoulos, A
    [J]. BLOOD, 2004, 104 (11) : 531A - 531A
  • [2] The role of antigen in the selection of the human V3-23 immunoglobulin heavy chain variable region gene
    Mackworth-Young, CG
    Harmer, IJ
    Mageed, RA
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2003, 134 (03): : 420 - 425
  • [3] Somatic mutation in V-H complementarity-determining region 2 and framework region 2 - Differential effects on antigen binding and Ig secretion
    Wiens, GD
    Heldwein, KA
    StenzelPoore, MP
    Rittenberg, MB
    [J]. JOURNAL OF IMMUNOLOGY, 1997, 159 (03): : 1293 - 1302
  • [4] Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER
    Souto-Carneiro, MM
    Longo, NS
    Russ, DE
    Sun, HW
    Lipsky, PE
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (11): : 6790 - 6802
  • [5] MYELOMA IG HEAVY-CHAIN-V REGION SEQUENCES REVEAL PRIOR ANTIGENIC SELECTION AND MARKED SOMATIC MUTATION BUT NO INTRACLONAL DIVERSITY
    VESCIO, RA
    CAO, J
    HONG, CH
    LEE, JC
    WU, CH
    DANIELIAN, MD
    WU, V
    NEWMAN, R
    LICHTENSTEIN, AK
    BERENSON, JR
    [J]. JOURNAL OF IMMUNOLOGY, 1995, 155 (05): : 2487 - 2497
  • [6] Absence of somatic hypermutation of immunoglobulin heavy chain variable region genes in precursor B-lymphoblastic lymphoma - A study of four cases in childhood and adolescence
    Hojo, H
    Sasaki, Y
    Nakamura, N
    Abe, M
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2001, 116 (05) : 673 - 682
  • [7] COMPLEMENTARITY-DETERMINING REGION-2 IS IMPLICATED IN THE BINDING OF STAPHYLOCOCCAL PROTEIN-A TO HUMAN-IMMUNOGLOBULIN V(H)III VARIABLE REGIONS
    RANDEN, I
    POTTER, KN
    LI, YC
    THOMPSON, KM
    PASCUAL, V
    FORRE, O
    NATVIG, JB
    CAPRA, JD
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (10) : 2682 - 2686
  • [8] Primary diffuse large B cell lymphoma of the stomach: analysis of somatic mutations in the rearranged immunoglobulin heavy chain variable genes indicates antigen selection
    A Driessen
    A Tierens
    N Ectors
    M Stul
    S Pittaluga
    K Geboes
    J Delabie
    C De Wolf-Peeters
    [J]. Leukemia, 1999, 13 : 1085 - 1092
  • [9] Primary diffuse large B cell lymphoma of the stomach: analysis of somatic mutations in the rearranged immunoglobulin heavy chain variable genes indicates antigen selection
    Driessen, A
    Tierens, A
    Ectors, N
    Stul, M
    Pittaluga, S
    Geboes, K
    Delabie, J
    De Wolf-Peeters, C
    [J]. LEUKEMIA, 1999, 13 (07) : 1085 - 1092
  • [10] Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization
    Gokmen, E
    Raaphorst, FM
    Boldt, DH
    Teale, JM
    [J]. BLOOD, 1998, 92 (08) : 2802 - 2814