Vms1 Relieves a Mitochondrial Import Chokehold

被引：1
|
作者：
Lamech, Lilian [1 ]
Haynes, Cole M. [2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA
[2] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, Worcester, MA 01655 USA
来源：
DEVELOPMENTAL CELL | 2017年 / 43卷 / 03期
关键词：
PROTEIN-QUALITY CONTROL; DEGRADATION;
D O I：
10.1016/j.devcel.2017.10.022
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria.
引用
收藏
页码：259 / 260
页数：2
相关论文
共 50 条
  • [1] Regulation of the mitochondrial protein quality control factor VMS1
    Fredrickson, Eric K.
    Nielson, Jason R.
    Hill, Christopher P.
    Rutter, Jared
    [J]. FASEB JOURNAL, 2017, 31
  • [2] Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis
    Su, Ting
    Izawa, Toshiaki
    Thoms, Matthias
    Yamashita, Yui
    Cheng, Jingdong
    Berninghausen, Otto
    Hartl, F. Ulrich
    Inada, Toshifumi
    Neupert, Walter
    Beckmann, Roland
    [J]. NATURE, 2019, 570 (7762) : 538 - +
  • [3] Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis
    Ting Su
    Toshiaki Izawa
    Matthias Thoms
    Yui Yamashita
    Jingdong Cheng
    Otto Berninghausen
    F. Ulrich Hartl
    Toshifumi Inada
    Walter Neupert
    Roland Beckmann
    [J]. Nature, 2019, 570 : 538 - 542
  • [4] Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis
    Izawa, Toshiaki
    Park, Sae-Hun
    Zhao, Liang
    Hartl, F. Ulrich
    Neupert, Walter
    [J]. CELL, 2017, 171 (04) : 890 - +
  • [5] Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis
    Ting Su
    Toshiaki Izawa
    Matthias Thoms
    Yui Yamashita
    Jingdong Cheng
    Otto Berninghausen
    F. Ulrich Hartl
    Toshifumi Inada
    Walter Neupert
    Roland Beckmann
    [J]. Nature, 2019, 571 : E4 - E4
  • [6] Intramolecular interactions control Vms1 translocation to damaged mitochondria
    Heo, Jin-Mi
    Nielson, Jason R.
    Dephoure, Noah
    Gygi, Steven P.
    Rutter, Jared
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (09) : 1263 - 1273
  • [7] Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis (vol 570, pg 538, 2019)
    Su, Ting
    Izawa, Toshiaki
    Thoms, Matthias
    Yamashita, Yui
    Cheng, Jingdong
    Berninghausen, Otto
    Hartl, F. Ulrich
    Inada, Toshifumi
    Neupert, Walter
    Beckmann, Roland
    [J]. NATURE, 2019, 571 (7764) : E4 - E4
  • [8] Vms1: ACytosolic CAT-Tailing Antagonist to Protect Mitochondria
    Kreft, Stefan G.
    Deuerling, Elke
    [J]. TRENDS IN CELL BIOLOGY, 2018, 28 (01) : 3 - 5
  • [9] Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria
    Nielson, Jason R.
    Fredrickson, Eric K.
    Waller, T. Cameron
    Rendon, Olga Zurita
    Schubert, Heidi L.
    Lin, Zhenjian
    Hill, Christopher P.
    Rutter, Jared
    [J]. MOLECULAR CELL, 2017, 68 (04) : 673 - +
  • [10] Sterol oxidation mediates stress-responsive Vms1 translocation to mitochondria.
    Fredrickson, E.
    Rutter, J.
    Hill, C. P.
    Nielson, J. R.
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2017, 28
12345