Chiral separation of some non-steroidal anti-inflammatory drugs on tartardiamide DMB chiral stationary phase by HPLC

被引：15
|
作者：
Aboul-Enein, HY [1 ]
机构：
[1] King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia
来源：
JOURNAL OF SEPARATION SCIENCE | 2003年 / 26卷 / 6-7期
关键词：
enantiomers; stereoselectivity; tartardiamide-DMB CSP; non-steroidal anti-inflammatory drugs; chiral recognition; high performance liquid chromatography;
D O I：
10.1002/jssc.200390070
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Selected non-steroidal anti-inflammatory drugs (NSAIDs), namely racemic flurbiprofen, ibuprofen, fenprofen, tiaprofenic acid, ketoprofen, and tolmetin were resolved on Kromasil tartardiamide-DMB chiral stationary phase. Optimum resolution was achieved using a mobile phase consisting of hexane: tert-butyl methyl ether:acetic acid (75 : 25 : 0.1 v/v/v) at flow rate of 1 mL/min. The capacity (k), separation (alpha), and resolution factors (Rs) are reported. The mechanisms of chiral recognition between the analytes and the chiral selector are discussed.
引用
收藏
页码：521 / 524
页数：4
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