Mind the Gap: Lack of Association between KIR3DL1*004/HLA-Bw4-Induced Natural Killer Cell Function and Protection from HIV Infection

被引：26
|
作者：
Parsons, Matthew S. [1 ,2 ,3 ]
Boulet, Salix [1 ,2 ]
Song, Rujun [1 ,2 ,3 ]
Bruneau, Julie [6 ]
Shoukry, Naglaa H. [6 ]
Routy, Jean-Pierre [1 ,2 ,4 ,5 ]
Tsoukas, Christos M. [1 ,2 ,3 ]
Bernard, Nicole F. [1 ,2 ,3 ]
机构：
[1] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ H3G 1A4, Canada
[2] McGill Univ, Ctr Hlth, Div Clin Immunol & Allergy, Montreal, PQ H3G 1A4, Canada
[3] McGill Univ, Ctr Hlth, Div Expt Med, Montreal, PQ H3G 1A4, Canada
[4] McGill Univ, Ctr Hlth, Immunodeficiency Serv, Montreal, PQ H3G 1A4, Canada
[5] McGill Univ, Ctr Hlth, Div Hematol, Montreal, PQ H3G 1A4, Canada
[6] CHU Montreal, Hop St Luc, Ctr Rech, Montreal, PQ, Canada
来源：
JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷
基金：
加拿大健康研究院;
关键词：
COMPLEX CLASS-I; NK-CELLS; HLA-B; KIR3DL1; ALLELES; INDIVIDUALS; PROGRESSION; EXPRESSION; EDUCATION; RECEPTOR;
D O I：
10.1086/655966
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Several combinations of genes encoding KIR3DL1 alleles and their HLA-Bw4 ligands have been linked with favorable outcomes upon exposure to or infection with human immunodeficiency virus (HIV). Some protective KIR3DL1/HLA-Bw4 combinations confer elevated natural killer (NK) cell functional potential. The K562-stimulated functionality of NK cells from KIR3DL1*004/HLA-Bw4 and control genotype carriers was assessed by flow cytometry and found to be higher in KIR3DL1*004/HLA-Bw4 carriers. However, a comparison of the frequency of this combined genotype among HIV-exposed uninfected and HIV-infected subjects revealed no between-group differences. Thus, despite its ability to license NK cells, KIR3DL1*004/HLA-Bw4 is not associated with a reduced risk of infection.
引用
收藏
页码：S356 / S360
页数：5
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