Recurrent granulomatous cheilitis associated with Crohn's disease successfully treated with ustekinumab: case report and literature review

被引：8
|
作者：
Taxonera, Carlos [1 ]
Alba, Cristina [1 ]
Colmenares, Michel [1 ]
Olivares, David [1 ]
Rey, Enrique [1 ]
机构：
[1] Inst Invest Hosp Clin San Carlos IdISSC, Gastroenterol, Inflammatory Bowel Dis Unit, Hosp Clin San Carlo, Madrid, Spain
来源：
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2020年 / 13卷
关键词：
adalimumab; Crohn's disease; granulomatous cheilitis; infliximab; orofacial granulomatosis; ustekinumab; vedolizumab; MELKERSSON-ROSENTHAL-SYNDROME; OROFACIAL GRANULOMATOSIS; INFLIXIMAB; THERAPY; MANIFESTATIONS; CHILDREN;
D O I：
10.1177/1756284820934327
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Granulomatous cheilitis, characterized by persistent inflammation of the lips and a granulomatous histology, is sometimes associated with Crohn's disease and is a therapeutic challenge. Reported evidence indicates treatment with an anti-TNF agent (mainly infliximab) is the most recommended therapeutic option after failure of conventional treatments. The clinical case reported the effectiveness of ustekinumab, a monoclonal antibody against interleukins 12/23, to induce the remission of severe and recurrent granulomatous cheilitis in a patient with Crohn's disease.
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页数：6
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